Domosedan 10 mg/ml Detomidine hydrochloride 5 ml

 Domosedan 10 mg/ml Detomidine hydrochloride 5 ml

Domosedan 10 mg/ml Detomidine Hydrochloride

 

Presentation

A clear solution for injection containing Detomidine hydrochloride 10 mg/ml. Domosedan contains methyl hydroxybenzoate as a preservative.

Indications

Domosedan is a sedative with analgesic properties used with or without butorphanol to facilitate the handling of horses for examination, minor surgical interventions and other manipulations.

Dosage and administration

The following procedure is recommended: Use two sterile needles, one to fill the syringe from the bottle and one to inject the patient. Once the required dose has been withdrawn from the vial, the syringe should be removed from the needle. A separate sterile needle should be inserted into the injection site and the syringe connected to it. The needles should be discarded.

Domosedan alone for sedation

For parenteral use by intramuscular or slow intravenous injection. Onset of effect is more rapid following intravenous administration.

Dosage

 

 

 

Anticipated level of sedation

Light

Moderate

Profound

Dosage (IM or IV) mcg/kg

10 - 20

20 - 40

40 - 80

Dose (IM or IV) ml/100 kg

0.1 - 0.2

0.2-0.4

0.4 - 0.8

 

Domosedan with butorphanol for sedation

Dosage: 0.10 ml Domosedan/100 kg (10 mcg/kg detomidine hydrochloride) intravenously, followed within 5 minutes by a dose rate in the region of 25mcg/kg butorphanol (e.g. 0.25ml/100kg of a 10mg/ml solution), intravenously. Clinical experience has shown that 5mg detomidine (0.5ml Domosedan) and 10mg butorphanol (e.g. 1ml of a 10 mg/ml solution) affords effective, safe sedation in horses above 200 kg bodyweight.

Contra-indications and warnings

Before using any combinations consult the contraindications and warnings that appear on the other products' data sheets.

Contraindications

Do not administer to horses in the last month of pregnancy.

Do not use in conjunction with sympathomimetic amines or with intravenous potentiated sulphonamides.

It is always necessary to administer detomidine prior to ketamine and to allow sufficient time (5 minutes) for sedation to develop. The two agents must therefore never be administered simultaneously in the same syringe.

Do not use the butorphanol combination in horses suffering from colic.

Detomidine/butorphanol combination should not be used in horses with a history of liver disease or cardiac irregularities.

Precautions

The product should not be used in horses with pre-existing AV blocks, with severe coronary insufficiency, respiratory disease or chronic renal failure.

Careful consideration should be given prior to administration to animals in shock and to animals with liver or kidney disease.

Intravenous administration should be slow.

It is recommended that feed should be withheld for at least 12 hours prior to anaesthesia.

The horse should not be given water or feed before the drug effect has passed.

Routine safety measures should be employed to protect practitioners and handlers.

Adverse reactions

Injection may cause benign reversible cardiac arrhythmia. Side effects such as sweating, incoordination of limbs and muscle tremor may occur after administration. A diuretic effect is usually observed within 45 to 60 minutes after treatment.

Use during pregnancy, lactation

Not to be used in mares in the last month of pregnancy.

Interactions

Domosedan should not be mixed with other products.

Use with care with other sedatives and anaesthetics because of an additive/synergistic effect.

Where appropriate the product may be used in conjunction with local anaesthetic agents.

Induction of anaesthesia with detomidine and ketamine has been used prior to maintenance with halothane. Because of the nature of the induction agents, the effects of halothane may be delayed and special care must be taken to avoid over-dosage. When detomidine is used as a premedication prior to general anaesthesia, the product may delay onset of induction.

Use in conjunction with sympathomimetic amines and intravenous potentiated sulphonamides is contra-indicated.

Overdose

In cases of overdose, or should the effects become life-threatening, an alpha-2 agonist (atipamezole) is recommended (5 - 10 times the dose of detomidine in mcg/kg)

Routine safety measures should be employed to protect practitioners and handlers.

In the case of accidental oral intake or self-injection, seek medical advice immediately and show the package leaflet to the doctor but do not drive a car as sedation and changes in blood pressure may occur. Avoid skin, eye or mucosal contact. Immediately after exposure, wash the exposed skin with large amounts of fresh water. Remove contaminated clothes that are in direct contact with skin. In the case of accidental contact of the product with eyes, rinse with large amounts of fresh water. If symptoms occur, seek the advice of a doctor. If pregnant women handle the product, special caution should be observed not to self inject as uterine contractions and decreased foetal blood pressure may occur after accidental systemic exposure.

Withdrawal Period

Horses (meat and offal): 1 day


Write a review

Note: HTML is not translated!
    Bad           Good

  • Product Code: Domosedan 10 mg/ml Detomidine hydrochloride 5 ml
  • Availability: In Stock
  • €117.45